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Do opioids make pain worse?

The opium poppy is arguably the oldest painkiller known to man, with its use being described by the ancient civilizations. Opium mimics the body’s home-made painkillers — endorphins and the like — and has given rise to the modern class of drugs called opioids that include morphine, fentanyl, methadone, and oxycodone. Opioids are very effective, and they remain the cornerstone of moderate to severe pain management. read more

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